Researchers are developing an animal model for a rare
genetic disorder known as osteogenesis imperfecta. Children born with this
disorder have a genetic mutation that prevents them from forming strong bones.
Neonates usually have many broken bones at birth and usually die within 6
months, or within a year at most. They usually also have severe brain damage,
organ damage, and a variety of infections. Researchers plan to develop a
transgenic mouse with a genetic defect that results in a condition similar to
osteogenesis imperfecta. They will study the etiology of the disease in mice as
well as a variety of treatment modalities. Do you have an ethical problem with this
experiment? Why or why not?
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