Dr. Reno is a junior investigator who has just received her
fi rst major NIH grant. She has used NIH funds to create a transgenic mouse
model to study depression. The mouse has a genetic defect the leads to an
underproduction of serotonin. She has used the model to show how a compound
found in an herbal medicine increases serotonin levels in mice and also
produces effects associated with normal (i.e., nondepressed) behavior, such as
normal levels of exercise and normal sleep patterns. Dr. Reno applies for a
patent on this compound with the intent of eventually testing it on human
subjects. She also publishes a paper in a high-impact journal describing her
work with the mouse model. Almost immediately after the paper appears in print,
she receives dozens of requests from researchers who would like to use
hertransgenic mice in their own research. Dr. Reno is fl attered but also
overwhelmed. She has barely enough mice for her own work, and she doesn’t want
to turn her laboratory into a factory for producing mice for someone else’s
research.
• How should Dr. Reno deal with these requests to share
transgenic mice?
• Does she have an obligation to the share the mice?
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